James Humphreys (January 15, 1748 – February 2, 1810) was a printer, publisher, merchant and politician in Nova Scotia and Pennsylvania.
He represented Shelburne County in the Nova Scotia House of Assembly from 1793 to 1796.
Humphreys then apprenticed as a printer with William Bradford and established his own business in 1772, printing books and a number of pamphlets.
By 1797, he had returned to Philadelphia and, after failing to establish another newspaper there, resumed book printing in partnership with some of his sons and daughters.
Humphreys published an 1802 edition of Lyrical Ballads by William Wordsworth and Samuel Taylor Coleridge.