James "Pee Wee" Madison (May 4, 1935 – January 7, 2008)[1] was an American blues guitar player.

Born in Osceola, Arkansas, he moved to Chicago in the late 1950s, molding his musicianship after that of Little Walter.

[2] His big chance came when he joined the band of Muddy Waters in 1963, replacing guitarist Pat Hare who was incarcerated for killing his girlfriend.

[4] While traveling through Illinois with Muddy Waters on October 26, 1969, Madison was injured in an automobile accident.

The young couple that collided with the band's vehicle on U.S. Route 45 were both killed in the accident.