James Mosgrove (June 14, 1821 – November 27, 1900) was a Greenback member of the U.S. House of Representatives from Pennsylvania.

James Mosgrove was born in Kittanning, Pennsylvania, on June 14, 1821.

Prior to his public service career, Mosgrove was engaged in the iron business.

In 1878, he was an unsuccessful candidate for elected office.

He also declined to be a candidate for the Democratic nomination for governor.