Baptised on 17 July 1741 in Lincoln, Nixon studied at the Royal Academy Schools from March 1769.
[2] Nixon was a leading miniaturist of his time, and held the appointments of limner to the Prince of Wales and miniature-painter to the Duchess of York; in 1778 he was elected Associate of the Royal Academy.
[1] Nixon painted Elizabeth Farren and other theatrical celebrities, as well as figures of Shakespearean characters.
He sent some portraits in oil to the Royal Academy, and in 1786 a series of ten designs illustrating Tristram Shandy.
His portraits of Dr. Francis Willis, the Duchess of Devonshire, Elizabeth Hartley, and the sisters Jenny and Nelly Bennet were engraved.