Among his siblings included Jediah and John, both New York State Senators.

[1] After the American Revolution, the Prendergast family, consisting of the children, grandchildren, and servants, traveled to Wheeling, Virginia and then to Louisville, Kentucky, before they arrived in Memphis, Tennessee.

He brought his family, along with John and Mary Bowers, to Chautauqua County in 1810, and stayed with his brother Matthew during the winter of 1810–1811.

In 1815, Prendergast was nominated for New York State Assembly as a member of the Federalist Party, along with Daniel Chapin of Buffalo.

[1] In 1836, he sold his land in Jamestown and moved to Ripley, in the northern part of the county.