The James Weir Building is an academic building in Glasgow City Centre, Scotland, United Kingdom and is part of the University of Strathclyde’s John Anderson Campus, situated between the Townhead and Merchant City districts of the area.

The James Weir Building was designed by Peter Williams of the local architectural firm Shanks, Wylie and Underwood (Williams later designed other prolific academic buildings in the area such as the Met Tower and the Central College of Commerce) and was constructed over the period 1956–1964 in two distinct phases as a north eastern extension to the Royal College Building, which allowed the expanded Royal College to attain the royal charter and become the University of Strathclyde.

The college (before it became the University of Strathclyde) sent out documents that a beneficiary could sign, in the process stating how much funding they would put forward to the project.

Remaining tenants within tenement housing located on Montrose Street had their tenancies terminated in April 1949 to allow site clearance to take place.

Governors wished to proceed quickly with the first stage of development which was estimated to cost £445,000, towards which Government grants amounting to £334,000 had already been advised.

The Governors of the college would have to raise £350,000 on their own initiative to complete, equip the building and to provide a moderate endowment for research.

[9] The fire took place in the chemical engineering department and was complicated by the presence of hazardous materials.

[10] After the fire some classes have been forced to relocate to nearby buildings including the International Christian College (now demolished) and Vertigo in the Student Union.

In 2000, the lecture floor on Level 4 received a comprehensive redevelopment which saw the first of the University's Interactive Teaching Clusters built.

Between 2004 and the present, the James Weir Building has had a recent major refurbishment (worth over a million pounds) on levels 1 and 2.

[15] Six of the ground floor laboratories were redeveloped, with the removal of obsolete machinery and equipment allowing extra mezzanine space to be constructed within.