James Henderson Williams (November 10, 1740 – October 7, 1780) was an American pioneer, farmer, and miller from Ninety-Six District in South Carolina.

[1] His siblings included James, Joseph, John, Daniel, Henry, Mariah Goodman, and Mary Mitchell.

He succeeded in organizing a militia group, but pressure from Britain and her Indian allies meant that Williams always had to leave some troops behind for home defense.

Williams led forces of local men into action at nearby Briar Creek and Stono Ferry, and as far afield as the expedition to the Second Battle of Savannah.

Williams' original hastily dug grave was on John B. Mintz's property, on top of a hill at the intersection of Buffalo Creek and the Broad River, near Blacksburg, South Carolina.

His body was dug up in May 1898 and kept secret for several years before being re-interred on the lawn in front of the Administration building, on Limestone Street in Gaffney, South Carolina and marked by a large memorial.

His death was unknown for several weeks and during that time the South Carolina Provincial Congress had promoted Col. James Williams to the rank of brigadier general; the commission could not be delivered.