Jamesville is located in Onondaga County, New York, United States, part of the greater Syracuse area.

[2] It was settled in the early Federal period after the American Revolutionary War, when the Iroquois tribes had been forced to cede their lands in New York to the United States.

The Dr. John Ives House, Saint Mark's Church, and Southwood Two-Teacher School are listed on the National Register of Historic Places.

[3] On January 16, 2007, a New York City company, Empire Synfuel LLC, submitted an application for site plan approval for a proposed coal gasification plant in Jamesville.

The proposal faced opposition from area residents and town board members, who were concerned about such environmental issues as the proximity of the village's elementary school.