Seneca Knolls is a hamlet (and census-designated place) in Onondaga County, New York, United States.

Seneca Knolls is in the eastern part of the town of Van Buren.

[2] According to the United States Census Bureau, the CDP has a total area of 1.2 square miles (3.1 km2), all land.

The community lies mostly between Interstate 690 and New York State Route 48 and is northwest of Onondaga Lake.

22.7% of all households were made up of individuals, and 8.9% had someone living alone who was 65 years of age or older.