James Joseph D'Antona (born May 12, 1982) is a former professional Major League Baseball infielder with the Arizona Diamondbacks.

[1] A first and third baseman, D'Antona played college baseball for Wake Forest University, where he had a .354 career batting average and 58 home runs.

In 2004, he played with High Single-A Lancaster, where he batted .315 and earned a late-season promotion to Double-A El Paso.

With Double-A Tennessee in 2005, D'Antona struggled to hit for average, only .249, which caused his home run total to drop to 9.

In 2008, D'Antona batted near .400 for the first 2⁠1/2⁠ months, was selected to play in the All-Star Futures Game, and won the Triple-A Home Run Derby in triple overtime against Detroit Tigers minor league infielder Mike Hessman.