James was educated at North Bridge House School, and studied business at Regent's University London.
[4][5] In the 2012 London mayor election, Reuben served as chairman of Boris Johnson's re-election campaign committee.
[9] On 8 October 2018, Jamie Reuben was appointed to the board of London-based football club Queen's Park Rangers.
[13] In March 2021, Reuben was appointed co-chair to the Growth Board of homelessness charity Centrepoint.
[14] In October 2021, Reuben became co-owner of Newcastle United Football Club, alongside PCP Capital Partners and the Public Investment Fund of Saudi Arabia.