To the east, the Indus separates it from Shaheed Benazirabad, Matiari and Hyderabad districts.

The district is rich in limestone, salika sand, gravels, silt, and marble.

Industrial areas and Power plants are using manpower, while towns are providing business opportunities to the residents.

The inhabitants of mountainous area keep cattle while Mallahs o Manchhar Lake earn their living by fishing.

Approximately 20% of the district population works for the federal and provincial government.

Two main town's of Sindh Industrial and Trading Estate are in Jamshoro District, Kotri and Nooriabad.