He lectured on mathematics and astronomy and was also a personal astrologer and physician of kings Wenceslaus IV of Bohemia and his brother Holy Roman Emperor Sigismund.
In 1406, he worked at the parish school of the St. Nicolas Church in Malá Strana in Prague.
He had a good relationship with Enea Silvio Bartolomeo Piccolomini (later Pope Pius II), their correspondence from the years 1445–1447 has been preserved.
[1] Šindel's astronomical tables and maps were allegedly still used by Tycho Brahe.
Based on his suggestion and calculations, Mikuláš of Kadaň constructed the Prague Orloj clock in 1410.