He was educated at the Sint-Jan Berchmanscollege Catholic School in Genk before studying for a degree in computer science at the Vrije Universiteit Brussel followed by an MBA in business at the University of Antwerp.

The broadening operation led by Hugo Schiltz and Jaak Gabriëls also proved difficult for him to digest, as did the election of the 'left-wing' member of parliament Herman Lauwers, national chairman of the VVKSM Scouts from Brasschaat.

As a result He left the party in 1988 after the broadening operation wanted by Hugo Schiltz and Jaak Gabriëls, and moved with Peter De Roover to the advocacy group Vlaamse Volksbeweging (VVB).

Jambon is believed to have helped in establishing a chapter of the far-right Flemish nationalist political party Vlaams Blok in the city of Brasschaat in the late 1980s along with Luc Sevenhans.

In a source of retrospective debate, Janbon is said to have founded the branch on the advice of Vlaams Blok politician Gerolf Annemans after he and Sevenhans both left the Volksunie.

This forum died a quiet death in 1996 after the much more radical Werkgroep Radicalisering IJzerbedevaart, consisting of Voorpost, VNJ, NSV and others, then started the current IJzerwake in Steenstrate and Ypres.

On 18 February 2006 Jambon resigned from the Vlaamse Volksbeweging to work for the New Flemish Alliance (N-VA) in order to prepare the partition of Belgium.

At the municipal elections on 8 October 2006, Jambon received 565 preferential votes and from January 2007 he was alderman for finance and local economy.

In mid-March 2007, he stood as a candidate in Antwerp on the list of N-VA and CD&V for the federal parliamentary elections, where he obtained 9,099 preferential votes.

After the vote on the split of the electoral district of Brussels-Halle-Vilvoorde on 7 November 2007 Jambon declared that the N-VA would not step into an orange-blue emergency cabinet if there was no prospect of state reform.

It was remarkable that people's representatives so openly called for the interests of one business sector to be defended in an 'informal club'.In the 2012 provincial council elections, Jambon was the last one on the list in the canton of Antwerp in the municipality of Brasschaat, where the N-VA obtained 39 percent of the votes.

With the governmental crisis surrounding the UN migration treaty, the Michel I government fell and Jambon's ministerial mandate came to an end on 9 December 2018.

Jambon thereby took the place of his party leader Bart De Wever, who was a candidate for prime minister during the election campaign.

In a meeting with the Parliamentary Committees on Justice and Home Affairs, Interior Minister Pieter De Crem indicated that Jambon was aware of the incident at the time, which he would have previously denied.

[19][20] Jambon claimed after De Crem's revelation that he had no recollection of it and that the file shows that neither he nor his cabinet had found out that the police had acted in a problematic manner.

This was brought out for the first time in 2007 by Karel De Gucht on VRT, in an election debate with Yves Leterme, who was then working with CD&V and N-VA.