She was married to Isaac Asimov from 1973 until his death in 1992, and they collaborated on a number of science fiction books aimed at young readers, including the Norby series.

[4] After her marriage to Isaac Asimov, she continued to practice psychiatry and psychoanalysis under the name Janet O. Jeppson, and she published medical papers under that name.

[10] Despite Jeppson's upbringing in the Church of Jesus Christ of Latter-day Saints,[11] their marriage was officiated by a leader of Ethical Culture, a humanist religious group that Janet later joined.

[10] Their marriage lasted until Isaac's death in 1992 from complications relating to HIV, contracted from a 1983 blood transfusion during bypass surgery.

[13] Janet reportedly consulted medical texts after Isaac began exhibiting symptoms, and she requested an HIV test be performed.