Janie Lou Gibbs (née Hickox; December 25, 1932 – February 7, 2010) was an American serial killer from Cordele, Georgia, who killed her three sons, a grandson, and her husband, by poisoning them with arsenic in 1966 and 1967.

Gibbs was not suspected of any wrongdoing, and she again donated a large portion of her life insurance payout to the local church.

Doctors listed his cause of death as a rare muscular disorder, and for a third time, Gibbs donated most of the life insurance money to the church.

Following the sudden deaths of a previously healthy young man and his infant son, the family physician became suspicious and referred the case to the state crime lab.

Autopsies conducted in the cemetery revealed each of the five murdered members of the Gibbs household had arsenic present in their bodies.