3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01, 5E1E, 5HX8, 5IXD, 5IXI371616451ENSG00000162434ENSMUSG00000028530P23458P52332NM_001321855NM_001321856NM_001321857NM_146145NM_013567NP_001308785NP_001308786NP_002218n/aJAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines.

[5] Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families.

Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling.

[6] Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.

[7] Janus kinase 1 has been shown to interact with: