She starred as Carly Lever, the head of pathology, in the ABC medical drama The Good Doctor.

Nicole studied theatre, dance, voice and studio art at Catawba College in Salisbury, North Carolina.

[1] In 2017, she voiced a femme "brown-skinned energetic creative" named Reina, for the Amazon Video animated series Danger & Eggs, who likes to build with her hands, is empowered by the world around her, and is the best friend of one of the protagonists.

She also voiced Keisha, the protagonist and narrator on Alice Isn't Dead, a podcast by Night Vale co-writer Joseph Fink.

[6] She was featured in the 2010 OUT 100 list in Out, and was photographed alongside Bruno Tonioli, Armistead Maupin, and Bill Silva for the issue.