She began her career in 2001, chosen by Nanni Moretti for his award-winning The Son's Room, receiving the Guglielmo Biraghi prize as Best New Talent of the Year.

In 2004, she won a Nastro d'Argento for The Best of Youth (La meglio gioventù).

In 2022, Trinca made her feature-length directorial debut with Marcel!,[1] which premiered at the 75th Cannes Festival.

The film, which also includes Leïla Bekhti, achieved distribution deals in 2024.

[2] In June 2024, Trinca was invited to become a member of the Academy of Motion Picture Arts and Sciences.