He played college football at Western Michigan, where he was twice recognized as the conference defensive player of the year.

Babin also played for the Seattle Seahawks, Kansas City Chiefs, Tennessee Titans, Philadelphia Eagles, Jacksonville Jaguars, New York Jets, Baltimore Ravens and Arizona Cardinals.

[1] In football, he was a two-time team Defensive MVP, and was an All-Kalamazoo Valley Association first-team choice as a senior.

Babin came back from a broken leg during his senior year, playing in the last three games and earning a scholarship from Western Michigan University.

Babin started 25 of 47 games at Western Michigan, setting Broncos career marks in sacks (38) and tackles for loss (75).

[10] On September 1, 2007, Babin was acquired by the Seattle Seahawks from the Houston Texans in exchange for safety Michael Boulware.

[11] He was released by the Seahawks on September 17, 2008, after the team acquired wide receiver Keary Colbert from the Denver Broncos.

[15] Babin's lone season with Titans proved to be one of his best, recording 58 tackles, 12.5 sacks, and two forced fumbles, which led to him being named to the 2011 Pro Bowl, the first appearance of his career.

[18] Following his Pro Bowl season, Babin signed a five-year deal with the Eagles worth approximately $28 million.

[19] This deal included guarantees in the $5–6 million range and reunited him with former Titans defensive line coach Jim Washburn.

In Week 1 of the 2011 regular season against the St. Louis Rams, Babin had two sacks, which matched his previous total during his last stint with the Eagles.

[35][36] On January 12, 2016, Babin signed with the Arizona Cardinals to add depth as an outside linebacker for the postseason after Alex Okafor was lost to an injury.