Locasale graduated summa cum laude from Rutgers University with a dual degree in Chemistry and Physics.
While completing his undergraduate degree, he received initial training in research in biochemistry and structural biology under Helen Berman.
[13][14][15] His recent work which has gained widespread public attention[16][17][18][19] has focused on the effects on dietary methionine restriction and diet in general as a therapeutic approach[20][21] to extend lifespan and shape tumor response to therapy.
He has also maintained advisory roles at a number of federal, private and international scientific agencies including the National Institutes of Health, the American Cancer Society, and the Israel Science Foundation.
[citation needed] He is also widely accomplished in academic mentoring with students and trainees having received the nation's highest honors at the undergraduate, doctoral, and postdoctorals levels[30][31][failed verification].