Schwartzman's other films include Spun (2003), I Heart Huckabees (2004), Marie Antoinette (2006), Funny People (2009), Saving Mr. Banks (2013), Big Eyes (2014), Klaus (2019), The Hunger Games: The Ballad of Songbirds & Snakes (2023), and Queer (2024).

Schwartzman made a cameo appearance as Ringo Starr in the biopic spoof Walk Hard: The Dewey Cox Story.

[4] He starred in the HBO show Bored to Death as a writer who moonlights as a private detective and puts himself up for hire on Craigslist.

In 2010, he played Gideon Graves in Scott Pilgrim vs. the World, the film adaptation of the comics by Bryan Lee O'Malley.

In 2011, Schwartzman made a cameo appearance as Vincent van Gogh in the Beastie Boys' short film Fight for Your Right Revisited.

In 2020, he starred as Italian crime boss Josto Fadda in the fourth season of the FX anthology series Fargo.

He appeared in the music video for the rock remix of "It's All About the Benjamins" by Puff Daddy, and contributed to Ben Lee's 2005 album Awake Is the New Sleep.

It had musical contributions by members of Incubus, as well as appearances by actresses Zooey Deschanel and Kirsten Dunst and Schwartzman's brother Robert.

In 2009, he composed the theme song to his HBO series Bored to Death, in which he also starred, under his Coconut Records title.

The original soundtrack is downloadable, as well as available in vinyl LP, on Coconut Records' official Cinder Block store.

Schwartzman married his longtime girlfriend, Brady Cunningham, an art and design director, at their home in the San Fernando Valley on July 11, 2009.