His MLB career spanned nine seasons from 2000 through 2008 for the New York Mets (2000), Tampa Bay Devil Rays (2000-2003), Minnesota Twins (2005-2007), and Cleveland Indians (2008).

He finished his collegiate career first on A&M's all-time list for hits and stolen bases, was second in batting average, and third in at-bats.

[3] He made his major league debut that day against the Baltimore Orioles, going 2-for-3 with a sacrifice hit and RBI in the 4–2 loss.

[7] Tyner played in 37 games with the Devil Rays after the trade, batting .241 with 8 RBI and six stolen bases in seven attempts.

[6] In 2001, Tyner established himself as a good baserunner, collecting a then club record and personal career best 31 stolen bases.

The ballclub had arranged to honor him by presenting his bobblehead to the first 10,000 fans attending a game against the Oakland Athletics at Tropicana Field on June 2, 2002.

After sitting in storage for a while, they were given to the Pinellas County Education Foundation, who distributed them students in their business and commerce program.

[6] Tyner spent the entire 2004 season with two Triple-A teams, hitting .309 with a home run, 23 stolen bases and 32 RBI in 102 combined games.

[6] He enjoyed a solid 2005 season with the Triple-A Rochester Red Wings, batting .286 with a home run, 18 stolen bases and 36 RBI in 133 games.

[6] Tyner returned to the Twins on July 14, 2006, due to injuries to outfielders Shannon Stewart and Jason Kubel.

[15] Tyner's scrappy play, swift speed, and small ball mentality fit well with much of the Twins' mantra.

Nicknamed "The Piranhas" by Chicago White Sox manager Ozzie Guillén, the Twins came to embrace the term as affirmation of their selfless, aggressive play.

[24] Prior to 2004, Tyner had a severe home run drought until he hit one in a minor league game in Richmond in 2004.

Tyner finally hit his first (and only) major league home run against the Cleveland Indians on July 28, 2007, against Jake Westbrook.