Jasper Avenue is an arterial road in central Edmonton, Alberta, and is the city's main street.

Jasper Avenue passes the community of Wîhkwêntôwin through mixed retail and high density residential.

East of 109 Street, Jasper Avenue passes through the downtown core and is home to many of Edmonton's oldest heritage buildings (for example the Hotel Macdonald) and some of Edmonton's tallest office towers, including Canadian Western Bank Place and Rice Howard Place.

East of 97 Street, Jasper Avenue departs from both the downtown core and the 101 Avenue alignment, running northeast along the North Saskatchewan River valley through the community of Boyle Street.

While slow reinvestment continued into the 2000s, the downtown core has recently seen increased development, such as the rise of the Warehouse District and Ice District to the north, resulting in increased activity and redevelopment along Jasper Avenue.