[1] Known as natural actress, in a career spanning over 5 decades she received nine state Nandi Awards for her acting in works such as Jyothi (1976), Idi Katha Kaadu (1979), Premabhishekam (1981), Meghasandesam (1982), and Dharmaatmudu (1983).

[1] She has garnered five Filmfare Awards South, for her performances in Jyothi (1976), Aame Katha (1977), Gruha Pravesam (1982), Amma Nanna O Tamila Ammayi (2004), and Kotha Bangaru Lokam (2008).

Jayasudha served as Member, Legislative Assembly, from Secunderabad constituency during 2009–2014 in the erstwhile combined Government of Andhra Pradesh.

She acted in a number of films in Telugu and Tamil mostly under Balachander's direction Sollathaan Ninaikkiren (1973), Naan Avanillai (1974) and Apoorva Raagangal and in Idi Katha Kaadu with Chiranjeevi.

In commercial cinema, she received a huge break when she starred in Adavi Ramudu (1977), which broke box office records.

[4] She has made her unique space in the Telugu cinema industry amidst a huge competition between her contemporary actresses Sridevi and Jayaprada.