Jayess is an unincorporated community in Lawrence County, Mississippi, United States.

[2] The Butterfield Company laid down a railroad through Jayess in 1912 to transport timber being harvested in the area to the company's sawmill in Norfield, approximately 15 mi (24 km) west of Jayess.

Butterfield's initials were used until the Postal Department changed it in when opened in 1912, to create the name "Jayess.".

[3][5] A klavern of the Ku Klux Klan was located in Jayess during the early 1960s.

[7] Located west of Jayess is the Boyd-Cothern House, constructed in 1837, and listed on the National Register of Historic Places in 1980.