Jaylen Guy Twyman (born July 19, 1999) is an American professional football defensive end.

He played college football for the Pittsburgh Panthers and was selected by the Minnesota Vikings in the sixth round of the 2021 NFL draft.

[5] Prior to his sophomore season in 2019, Twyman changed his number from 55 to 97 in honor of former Pittsburgh defensive tackle Aaron Donald.

[20] On December 24, 2023, Twyman signed with the Birmingham Stallions of the United States Football League (USFL).

[26] On June 21, 2021, Twyman suffered four gunshot wounds when bullets hit the car he was riding in while he was visiting family in Washington D.C.[27]