He played college football at Virginia Tech and was selected by the Vikings in the first round of the 2021 NFL draft.

He attended Riverdale Baptist School in Upper Marlboro, Maryland, where he played at left tackle for their football team.

[5] Following the 2020 season, Darrisaw declared for the 2021 NFL draft, in which he was selected by the Minnesota Vikings in the first round with the 23rd overall pick.

[13] On July 23, 2024, the Vikings and Darrisaw agreed to a four-year contract extension worth up to $113 million.

[14] In Week 8 of the 2024 NFL season, Darrisaw suffered a knee injury in a game between the Vikings and the Los Angeles Rams.