He played college football for the Iowa Hawkeyes, and was selected by the Minnesota Vikings in the fifth round of the 2021 NFL draft.

[8][9][10] In a shortened schedule during his senior season, Smith-Marsette recorded 25 receptions for 345 yards and 3 touchdowns – with two of those coming in his final college game.

[15] In Week 15 against the Chicago Bears, Smith-Marsette recorded his first career receiving touchdown.

[19] On October 21, 2022, Smith-Marsette was signed to the practice squad of the Kansas City Chiefs.

[20] He was elevated to the active roster prior to the season finale against the Las Vegas Raiders on January 6, 2023.

[23] On August 29, 2023, Smith-Marsette was traded to the Carolina Panthers in exchange for a swap of conditional 2025 seventh-rounders.