Vergne became a member of both the renowned Red Bull Junior Team and the French Automobile Sport Federation (FFSA), at the conclusion of the 2007 season.

It was the third consecutive year that a driver from the Red Bull Junior Team had won the title with Carlin, following on from Jaime Alguersuari in 2008 and Daniel Ricciardo in 2009.

[19] Despite only taking part in those meetings, Vergne finished 8th in the championship with four podium places, including his first series win at Silverstone after original race winner Esteban Guerrieri was disqualified for a technical infringement.

[22] However, after an appeal by his Carlin team, the Italian Motorsports Commission (CSAI) overturned the penalty and reinstated Vergne to the victory.

[23] Going into the final round of the season in Barcelona, Vergne trailed series leader and teammate Robert Wickens by two points, having taken five race victories including a double win at the Hungaroring.

Vergne had his first outing in a Formula One car at the Goodwood Festival of Speed in July 2010, driving a Red Bull RB5.

As well as suffering an engine-related issue which limited his running, he also had to leave the test early to travel to Macau for the end-of-season Formula Three race.

He did not take part in practice at the Indian Grand Prix to allow race drivers Jaime Alguersuari and Sébastien Buemi the maximum track time at the brand new circuit.

[31] Vergne was eleventh fastest during free practice at the Abu Dhabi Grand Prix, less than 0.3 seconds off the pace of Alguersuari, who was in the other STR6.

[33][34][35] On 14 December 2011, it was officially confirmed that Vergne would race for Toro Rosso in the 2012 season, alongside fellow Red Bull Junior Team member Daniel Ricciardo.

Vergne did not score points again until the Monaco Grand Prix, where he finished the race in eighth place, matching the best result of his career.

It was announced in 2013 that Vergne would drive again for Toro Rosso alongside rookie, 19-year-old Daniil Kvyat, who replaced Ricciardo at the team.

A wheel was not properly fitted in Friday practice ending his session early and earning him a 10 place grid penalty.

Vergne got off to a decent start getting through the Marussias and Caterhams while pulling away from Maldonado, but he retired for the third time in five races due to technical problems.

In Hungary, Vergne qualified eighth in changing conditions, but in the race he managed to get as high as second after pitting after a safety car; he held position in front of a battle which included Nico Rosberg, Sebastian Vettel and Lewis Hamilton.

At the Singapore Grand Prix, Vergne was able to equal his best-ever Formula One result with a sixth-place finish after a late charge which saw him pass Nico Hülkenberg, Kimi Räikkönen and Valtteri Bottas in the last four laps of the race, despite two five-second time penalties.

In August, Red Bull announced that Kvyat would be joined in the Toro Rosso team by Max Verstappen for 2015, leaving Vergne without a drive for the 2015 season.

[39] However, after Sebastian Vettel left Red Bull, it was announced that Kvyat would replace him, leaving a possible seat for Vergne at Toro Rosso for 2015.

[40] On 19 December 2014, it was announced that Vergne would join Ferrari in 2015, as test and development driver particularly in respect of simulator work.

On 8 August 2015, it was announced that Vergne would join the DS Virgin Racing team for the 2015–16 Formula E season, partnering Sam Bird.

After stringing together a consistent run of points finishes, Vergne clinched the title with a race to spare in New York, becoming the fourth different driver's champion in four seasons.

[49] It was announced that in the 2019–20 season, Vergne would be racing alongside António Félix da Costa, who would replace the TAG Heuer Porsche Formula E Team bound André Lotterer (who was his teammate from 2017 to 2019).

In October 2022, it was announced that Vergne would be joining the newly formed DS Penske outfit alongside reigning champion Stoffel Vandoorne for the 2023 season.

In an unexpected manner however, Vergne bounced back at the inaugural Hyderabad ePrix, where he scored his first victory of the season, defending from a hard-charging Nick Cassidy during the final sequence of laps.

[54][55] He would come close to the top in the next round in Cape Town, where an audacious overtake from former teammate Felix da Costa relegated Vergne to second by the checkered flag.

[58] After a 7th place finish at Misano, he broke the record for the most points scored in Formula E, previously held by di Grassi.