He joined the French Section of the Workers' International (SFIO) and was elected to the town council in Talence in 1935.

In July 1940, Audeguil was on the 80 members of the French assembly who voted against granting special powers to Marshal Philippe Pétain.

In 1941 he joined the Libération-Nord movement of the French Resistance and was a member of the Comité d'action socialiste, the clandestine form of the then-banned SFIO.

Following the defeat of German forces in France following the Allied landings in Normandy and Provence, Bordeaux was liberated by the French Forces of the Interior and Audeguil was appointed by the Provisional Government of the French Republic to act as mayor of the city.

He continued to represent Bordeaux in the National Assembly until 1951 when he gave up his seat due to ill health.