Jean-François-Auguste Le Dentu (21 June 1841, in Basse-Terre (Guadeloupe) – 26 October 1926, in Paris) was a French surgeon.

Beginning in 1863, he was an interne of medicine in Paris, later serving as an aide of anatomy (1864) and as a prosector to the medical faculty (1867).

In 1867, he received his doctorate with a thesis on venous circulation of the foot and leg, two years later obtaining his agrégation in surgery with the dissertation Des anomalies du testicule (testicular anomalies).

[1] Le Dentu is remembered for contributions made in the field of urosurgery; in 1875 being credited with achieving the first recorded occurrence of cure by nephrectomy in France,[2] and in 1898, with Joaquín Albarrán (1860–1912), performing the first nephroureterectomy for upper tract urothelial cancer.

With Pierre Delbet (1861-1957) and others, he published the multi-volume Traité de chirurgie clinique et opératoire (1901 et seq.).