A prolific cartoonist from 1959 until his death, Reiser made his debut in the publication La Gazette de Nectar for the Nicolas winery.

At a 2004 exhibition of his works in the Centre Pompidou, the entrance displayed the warning "Beware!

He founded the Franco-Belgian comics magazine Hara-Kiri in 1960 together with Fred and François Cavanna.

[3] Hara-Kiri was banned in 1970 by the French Minister of the Interior for mocking the just deceased Charles de Gaulle.

Reiser subsequently published his drawings in the follow-up magazine Charlie Hebdo and several other publications.