[4][5] She was founding artistic director of the Nevada Shakespeare Company for which she directed many acclaimed productions and played iconic characters including Maude Gonne and Lady Macbeth.

"[11] In September 2009, Simpson opened in Tucson, Arizona in the one-woman show, Coming In Hot, based on the book Powder: writing by women in the ranks from Vietnam to Iraq.

The show subsequently toured extensively, and garnered praise and also a fair amount of criticism by peace activists who thought it glorified war.

[19] Jeanmarie Simpson is a Lifetime Member of the Women's International League for Peace and Freedom (WILPF), serving as treasurer of the US Section as of March, 2016.

[21] After September 11, 2001, Simpson, a "self-described artivist," retreated from traditional theatre and began creating biographical works, political in nature, based on the lives of historical women.

[27][28] In 2024, audio/sign language productions of her plays The Jewish Question, Bambino Mio - Bright Little Flame (about the life of Maria Montessori), When Churchyards Yawn - (Hamlet in Purgatory), and Pineapple and Other Options were launched on YouTube.