Jeffrey Dean Twitty (born November 10, 1957) is a former Major League Baseball pitcher who played for one season.

He pitched for the Kansas City Royals for 13 games during the 1980 season.

Twitty attended Anderson College and the University of South Carolina.

At South Carolina, he set a single-season school record with 10 saves.

This biographical article relating to an American baseball pitcher born in the 1950s is a stub.