Portions of the highway are still named Jefferson Highway, including the portions that run through Jefferson Parish, Louisiana; East Baton Rouge Parish, Louisiana; Lee's Summit, Missouri; Osseo, Minnesota; and Wadena, Minnesota.

The southern terminus of the Jefferson Highway was in New Orleans, Louisiana at the intersection of St. Charles Avenue and Common Street.

[1] It is marked by a six-foot tall Georgia granite obelisk donated by the New Orleans chapter of the Daughters of the American Revolution.

[3] The original route (finalized in December 1916)[4] on today's roads is as follows: When Louisiana numbered its state highways in 1921, the entire length of the Jefferson Highway through Louisiana was designated as State Route 1.

Highways in Louisiana: US 61 from New Orleans to Baton Rouge (before it was rerouted onto the Airline Highway), US 71 from Baton Rouge to Clarence, US 171 from Mansfield to Shreveport, and US 80 from Shreveport west into Texas.