[4][5] PTH 75 is also part of an International Mid-Continent Trade Corridor, a network of highways and rail lines that connects cities in central regions of North America.

Proposals exist to upgrade the highway to an expressway or freeway standard, with bypasses at the town of Morris and Winnipeg neighbourhood of St. Norbert.

[2] Coinciding with the renumbering, the section between Emerson and Letellier was replaced with a more direct route approximately three kilometres (1.9 mi) west of the original one along the Red River.

[10] Further changes occurred in the 1950s when a more direct route was constructed in the Rural Municipality of Ritchot and bypasses were added around the communities of Ste.

[13] In 2020, the Canadian and Manitoba governments completed reconstruction of PTH 75's approach to the Emerson border crossing to accommodate future expansion at the port of entry.

These closures have a significant impact on the trucking industry, as PTH 75 is the primary transportation route between Winnipeg and the United States.

[18][19] In June 2020, the Manitoba government unveiled a plan to upgrade a portion of PR 246 to utilize it as a bypass when the dike at the north end of Morris is closed.