Jeffersonville High School is a public high school located in Jeffersonville, Indiana, United States.

This school district includes Charlestown addresses that are connected with the city of Jeffersonville.

While most schools in other counties have a majority European ratio of students, Jeffersonville total minority enrollment is 36%.

There was no PL221 or AYP calculation for the 2008–2009 school year because of a change in spring testing.

[6][7] Jeffersonville High School Red Devil student athletes have consistently brought home sectional, regional, and state championship victories, and other athletic accomplishments.