[2] He played college football for the Mississippi State Bulldogs and was selected by the Titans with the 19th pick in the 2019 NFL draft.

[14] In the playoffs, the Titans won upsets over the New England Patriots and the Baltimore Ravens before losing the AFC Championship game against eventual Super Bowl champions, Kansas City Chiefs, with Simmons playing in all three games.

In the Divisional Round against the Ravens, Simmons recovered a fumble forced by teammate Jurrell Casey on Lamar Jackson during the 28–12 road victory.

[15] During Week 3 against the Minnesota Vikings, Simmons recorded his first sack of the season during the 31–30 road victory.

[18] In Week 9 against the Chicago Bears, Simmons forced a fumble on running back David Montgomery that was recovered and returned by teammate Desmond King for a 63 yard touchdown during the 24–17 win.

He finished with 7.5 sacks, 54 total tackles (25 solo), seven passes defended, and one forced fumble.

[30] During the Titans' Week 11 loss to the Jacksonville Jaguars, Simmons scored his first NFL career touchdown on a 2-yard reception from quarterback Will Levis after being declared an eligible receiver.

[34] In the 2024 season, Simmons appeared in 16 games, finishing with a career high 76 total tackles (41 solo), five sacks, two forced fumbles, and four pass deflections.

[35] He earned his third Pro Bowl nomination as a replacement for injured defensive tackle Nnamdi Madubuike.

Simmons' brother, Dylan Bradley, played football at Southern Miss and then spent time with the Minnesota Vikings while his uncle, Jason Hatcher, played 10 total seasons with the Dallas Cowboys and Washington Redskins.

At this point in time — today is Wednesday — I’m focused on the Chiefs right now and helping my team win.