After growing up in Grand Rapids, Michigan, Brown moved to Chicago in 2000 to pursue an MFA at the School of the Art Institute.

[3] Established as a sensitive chronicler of bittersweet young-adult romance and nonsensical superhero parody, Brown's current direction remains split between autobiographical material, examining the minutiae of everyday life, whatever humorous fiction he feels in the mood for, and a wide range of fiction subjects in his series Sulk.

[7] His humorous works include Bighead (a super-hero parody), I Am Going To Be Small, Cat Getting Out Of A Bag, Kids Are Weird, and the graphic novel series Incredible Change-Bots.

"[12] Clumsy (2002) was originally self-published and was later published by Top Shelf Productions; as of 2007, an estimated 20,000 copies have been printed, according to an interview with Brown in The Comics Journal.

[16] Brown directed the animated music video for Death Cab for Cutie's "Your Heart is an Empty Room" (April 11, 2006).

The film, directed by Mohan, stars Lizzy Caplan, Alison Brie, Martin Starr, Geoffrey Arend, and Mark Webber.