Combs has been a prominent figure within the horror genre through most of his career, acting in eight films directed by Re-Animator director Stuart Gordon, such as From Beyond (1986), The Pit and the Pendulum (1991) and Castle Freak (1995).

[4] A graduate of Lompoc High School, as a senior, Combs played the lead role of Captain Fisby in a stage production of The Teahouse of the August Moon.

Combs then attended Santa Maria's Pacific Conservatory of the Performing Arts, and later developed his acting skills in the Professional Actor's Training Program at the University of Washington.

His voiceover roles include the Scarecrow in The New Batman Adventures, the Question in Justice League Unlimited, Ratchet in Transformers: Prime, the Leader in The Avengers: Earth's Mightiest Heroes, the Rat King in Teenage Mutant Ninja Turtles, and Brainiac in Injustice 2.

[11] Although it was supposed to run for only a month, it enjoyed much success and sold-out crowds, and was extended four times, until closing in Los Angeles on December 19, 2009.

The show had its East Coast debut on January 23 and 24, 2010 at Westminster Hall in Baltimore, MD, Poe's final resting place.

Along with many other actors, writers and creators of the show, Combs also had a cameo appearance as a holographic patron in Vic's Lounge in the final episode of Deep Space Nine.

He also voices the character of Romulan Commander Suldok for the Star Trek: Elite Force II video game.