Following the gameplay style of past Lego titles, players are able to control 180 characters from the Marvel Universe, each with their own unique abilities.

[7] Players can also explore the Marvel version of New York City, though they can only use a specific character and access buildings after the campaign is complete.

[13] Several characters, such as Iron Man, Nick Fury, Phil Coulson, Captain America, Black Widow, Hulk, Hawkeye, Loki, Thor, and Maria Hill, are modeled after their Marvel Cinematic Universe counterparts.

While searching the universe for planets for his master Galactus to consume, Silver Surfer is captured by Doctor Doom, and his board shattered into multiple "Cosmic Bricks".

Sandman and Abomination, hired by Doom to retrieve a brick, hold Grand Central Station hostage for it, but are defeated by Iron Man, Hulk, and Spider-Man.

Tasked with retrieving it, Black Widow, Hawkeye, and Spider-Man infiltrate Oscorp, but are forced to fight Venom while the Green Goblin escapes.

Iron Man and Hulk respond to a prison riot at the Raft, orchestrated by Magneto, Mystique, and Sabretooth to break out Loki and other villains.

Human Torch, Captain America, and Wolverine arrive to help defeat Red Skull, but inadvertently damage the portal generator.

Despite Mister Fantastic, Wolverine, and Hulk's attempts to stop him after defeating Mastermind, Magneto brings the Statue to an island filled with dinosaurs from the Savage Land, whereupon he uses a nuclear core stolen from Roxxon Industries to power his space station, Asteroid M. Captain America, Storm, and Thing pursue Magneto and defeat Rhino and Mystique, but fail to prevent the station's launch.

However, Loki reveals that he had manipulated Doom into building a flying pod, powered by the Tesseract, that will allow him to control Galactus and destroy Earth and Asgard.

While Nick Fury recovers the Tesseract, the heroes decide to give the villains a head start to avoid capture.

He added, "it's a warm and witty, multi-layered approach to the brand that ties in hundreds of Marvel's most iconic characters, settings, and stories".

Awards, the Academy of Interactive Arts & Sciences nominated Lego Marvel Super Heroes for "Family Game of the Year".

[5] A sequel titled Lego Marvel Super Heroes 2 was released for Microsoft Windows, Nintendo Switch, PlayStation 4, and Xbox One on 14 November 2017.