Jennerstown is a borough in Somerset County, Pennsylvania, United States.

The town, originally named Laurel Hill, was later renamed Jennerville in honor of Dr. Edward Jenner, discoverer of the smallpox vaccine.

The town and vicinity boast several buildings about 200 years old, which is not common in the surrounding area.

Throughout its history, Jennerstown has served primarily as a wayside for travelers and as a farming community.

Jennerstown has never been a large town, and its current population represents a peak.

Jennerstown is home to the Mountain Playhouse, one of the oldest venues for summer stock theatre in the United States.

Jennerstown Speedway is a popular summer destination for stock car racing.