For a time, the family stayed in Tuscola, Illinois; but eventually, they settled in Glendale, Arizona, when Garth was around 13 years old.

She studied dance and modeled, and was soon discovered at a local talent competition by Randy James, a Hollywood scout and manager.

Determined to become an actress, Garth would receive audition materials from Los Angeles that she would work on with Jean Fowler, a local acting coach.

Throughout the series, Garth's character went through occasional rough times and dealt with difficult issues in her personal life and with her family.

She was also instrumental in launching the spin-offs Melrose Place and 90210, with the character of Kelly becoming a continuity icon by appearing in most franchise episodes.

In 2005, she voiced her Beverly Hills, 90210 character Kelly Taylor, as well as an additional role in the Family Guy Presents Stewie Griffin: The Untold Story, in the episode segment “Bango Was His Name-Oh!”.

In the series, Garth's character, Kelly Taylor, is a Guidance Counselor at the fictional West Beverly High, where her half-sister Erin Silver attends.

The writers were eager to have her share scenes with former Beverly Hills, 90210 co-star Shannen Doherty, who reprised her role of Brenda Walsh.

In January 2010, Garth starred in an iVillage web series created by NBC Universal, Garden Party, about farm life, fresh produce, and healthy eating.

[14] On February 18, 2014, it was announced that production had started on The Jennie Garth Project, a ten-episode reality television series that aired on HGTV.

[15] Garth released a memoir entitled Deep Thoughts from a Hollywood Blonde with Emily Heckman on April 1, 2014.

[16] On May 3, 2017, Garth launched MomGiftBox.com, "an online subscription box of products to indulge, inspire and pamper moms with every purchase benefiting a charity.

[18] In November 2020, Garth began a podcast titled 9021OMG with Beverly Hills, 90210 co-star Tori Spelling, where the two, along with TV and radio personality Sisanie Villaclara, share memories from their time on the show.

"[33] She revealed in her memoir that she started suffering from anxiety at age 19, saying "I wouldn't say that I ever stepped over the line into full-blown agoraphobia, but I would say I definitely came close.