Spence has had principal roles on a number of television series, including Exes and Ohs, The 4400, Reunion and Write & Wrong.

[5] In 2012, Spence had roles in episodes of three network television shows, The Killing, Alcatraz and Supernatural.

[6] Spence had a recurring role in the science fiction television series Continuum, as Detective Betty Robertson, which aired from May 2012 to October 2015.

[7] In 2013, she had a featured role in the award-winning film Down River, which was written and directed by her husband Ben Immanuel.

[8][9] Spence was born and raised in Toronto, Ontario, by a British father and third-generation Japanese Canadian mother.