[2][3] The show starred Eliza Dushku as Tru Davies, a twenty-two-year-old medical school student who takes a job at the city morgue when her internship falls through.

When the corpse of a deceased woman seems to awaken and asks for her help, Tru discovers that she has the incredible power to relive that day in order to try to prevent that death.

Over the course of the series, Tru struggles to keep her secret, juggle her responsibilities with her complicated personal life, and learn to control her power.

The complete series also aired in Argentina, Australia, Brazil, Bulgaria, Chile, Colombia, Croatia, Czech Republic, Denmark, France, Germany, Greece, Hong Kong, Hungary, Iceland, India, Ireland, Israel, Italy, Japan, Malaysia, Pakistan, Portugal, South Africa, Singapore, Slovakia and the United Kingdom.

In summer 2006 Tru Calling made its public debut in Antena 3 and was later moved to its secondary channel, Neox, where the show had several reruns during the following years.