She specialized in portraits of notable and historic figures in the United States, but also made miniature, landscape, wildlife, still life, and genre paintings.

[2][3] She received a gold medal in music and art when she studied at the Wesleyan Female Institution in Staunton, Virginia.

[5] She later studied at the St. Louis School of Fine Arts[5] from 1892 to 1893, then in Venice sometime prior to 1895 with Italian painter Stefano Novo [de].

[6] Jenny Eakin Delony was one of the first woman artist from Arkansas to gain a reputation as a successful painter in the United States and internationally.

[7] She was a member of the American Artists Professional League,[4] Association of Women Painters and Sculptors and the National Arts Club, both in New York.

[4] Interested in feminist activism and the suffrage movement,[9] Rice left Fayetteville to set up a studio in New York in 1900.

Her painting of the 'La Grange College of Alabama is at the Museum of Tennessee Valley Historic Society, Tuscumbia, Alabama[4] Her work was shown with Maud Hold, Josephine Graham and Elsie Freund in 2007 at the "Women Artists in Arkansas" exhibition at the Historic Arkansas Museum.