Jensen used their own powerful version of the Austin DS5 4-litre straight-six engine (featuring triple H4 type SU carburettors, a high compression Weslake head with custom-made twin exhaust manifolds and an alloy baffled sump/oil cooler) in the 541S.

[6][7][8][9] A total of 127 cars were hand-built between 1960 and 1962 at Jensen's West Bromwich factory, most having GM-licensed Rolls-Royce hydramatic gearboxes.

It also suited the criteria of effortless speed and luxurious long-distance driving Jensen set for their new car, although twenty-two were fitted with Moss manual gear boxes at the request of their prospective owners.

[10] The Jensen 541S is also notable for being the first British car to have seat belts fitted as standard equipment.

Other safety equipment included a padded windscreen surround, fire extinguisher and first-aid kit.