Following military service in Zadar and further training at a clinic in Graz, Machiedo was first employed as the substitute town physician in Ston in early 1902.
[4] Following the assassination of Archduke Franz Ferdinand in Sarajevo in 1914, Machiedo was arrested on political grounds and held in custody pending trial in the Mamula Fortress and in Herceg Novi.
[5] Following the end of the war and the dissolution of Austria-Hungary, the National Council of Slovenes, Croats and Serbs appointed Machiedo a deputy member of the three-member provincial government of the former Austro-Hungarian crown land of Dalmatia.
The government consisted of Ivo Krstelj, Vjekoslav Škarica, and Josip Smodlaka (with deputies Prvislav Grisogono, Uroš Desnica, and Machiedo).
The provincial government administered the region in the run-up to the arrival of Allies of World War I and their occupation of the eastern Adriatic in 1918.
In early 1919, he was exiled by the Italian authorities to the island of Sardinia and then to the area of Ancona before being returned to Zadar.