An academy graduate of La Liga side Real Madrid, Jesé debuted for the senior team in 2011, making 94 appearances across all competitions for the club and scoring eighteen goals.

During his time in Madrid, which was disrupted by a serious knee injury in 2014, he won two Champions League medals, as well as a title in each of La Liga, the FIFA Club World Cup and the Copa del Rey.

Born in Las Palmas, Canary Islands, Jesé began his football career with local team Huracán in 2005, whom he joined from amateur side El Pilar.

[5][6] Jesé made his senior debut for the Real Madrid Castilla side on 16 January 2011 in a 5–0 Segunda División B home win over Universidad de Las Palmas.

His performance throughout the match, which included an assist for Dani Carvajal, drew early comparisons to fellow Real Madrid teammate and multiple Ballon d'Or winner, Cristiano Ronaldo.

[10] Having impressed with the reserve side during the first half of the season, Jesé was handed his senior debut on 12 December in the first round of the Copa del Rey, replacing Ronaldo for the final fifteen minutes of a 2–0 away triumph over SD Ponferradina.

[16] Jesé's lack of opportunity prompted agent Ginés Carvajal to publicly state that they would need to study options for the player's future if he was not permanently promoted to the first team the following year with the guarantee he would receive more playing time.

[17] In February 2013, in an interview with Marca, Jesé spoke out against his lack of senior game, stating that he was confident he was doing well enough to be granted an opportunity and, while he tried to learn as much as he could from Mourinho, he was a manager who surrounded himself with players who had already made their name.

[23] He ended the season with 22 goals to his name in 38 appearances, earning the Zarra Trophy for the top Spanish goalscorer in the league, and on 18 June reiterated his desire to stay at Real Madrid in order to fight for a place in the first team.

[24][25] While at the 2013 FIFA U-20 World Cup with Spain, Jesé was the subject of mass media speculation that he could be leaving Real Madrid following his lack of game-time with the first team the season before.

[26][27] Jesé was handed his Champions League debut on 2 October 2013 by new club manager Carlo Ancelotti, coming on as an 81st-minute substitute for Karim Benzema in a 4–0 group stage victory over F.C.

[31][32][33][34] On 18 March, however, just two minutes into Real Madrid's Champions League's round-of-16 second leg game against Schalke, Jesé suffered a complete tear of the anterior cruciate ligament in his right knee following a challenge from Sead Kolašinac and was sidelined for the remainder of the season.

[35][37][38] After spending nine months on the sidelines, Jesé returned from injury for the second leg of Real Madrid's tie against UE Cornellà in the Copa del Rey round of 32 on 2 December 2014, replacing Sami Khedira after 57 minutes and scoring the last goal of a 9–1 aggregate victory.

[43] Jesé struggled to break back into the first team following his injury though, starting only 3 of his 23 appearances for the season, and by the end of the campaign it was reported that he had grown frustrated at the club and was looking to leave in the summer.

In spite of his lack of game time, Jesé still managed to contribute 6 goals and 8 assists for the season and was regularly used as a back-up in the team's triumphant 2015–16 UEFA Champions League campaign.

During the build-up to the match, he revealed that he owed a debt to Real Madrid for welcoming him at the club and blamed the cruciate ligament injury he suffered as the reason for him not becoming a star with them.

[69] Upon the conclusion of Jesé's loan agreement, Las Palmas elected not to attempt to sign him permanently, with his poor overall performance, high salary demands and off-field behaviour ultimately contributing to the club's decision.

Teammate, and regular Stoke penalty-taker, Charlie Adam denied a visibly angered Jesé the opportunity the take the penalty but saw his effort saved by Brighton goalkeeper Mathew Ryan.

[82][83] Upon his return to PSG, Jesé indicated his eagerness to fight for a spot in the team but he and teammate Gonçalo Guedes were later excluded from new manager Thomas Tuchel's pre-season tour of Asia.

[85] At the turn of the year, with Jesé having not played a single match for the season, it was revealed that he had lost 7 kg after appointing a personal trainer as he looked to reintegrate himself into the team.

Spain were ultimately eliminated at hands of Uruguay in the quarter-finals but the nation's early exit from the competition did not prevent Jesé from earning the Bronze Boot award for ending as the tournament's third top goalscorer.

[117] His form at the tournament drew praise from Spanish journalist Guillem Balagué who claimed he was better than Real Madrid's new world-record signing Gareth Bale was at the same age.

[118] On 6 February 2014, although he was still eligible to play for the under-21s, Spain manager Vicente del Bosque revealed that Jesé was in his plans ahead of the 2014 FIFA World Cup in Brazil.

[119] However, his chances of taking part at the tournament were ended in March when he ruptured his anterior cruciate ligament while playing for Real Madrid, with Del Bosque describing the situation as "a blow".

[124][125] In 2013, in his role as the club's sporting director at the time, Zinedine Zidane declared himself an admirer of Jesé's direct style of football and goal scoring ability.

[126] Following Jesé's promotion to Real Madrid's first team in 2013, manager Carlo Ancelotti played him in a winger position, where he could cut inside from the wing both with the ball and without, to create chances and score goals.

"[136] In 2014, just a week after suffering a cruciate ligament injury with Real Madrid, Jesé had to be rescued when a suspected gas explosion set fire to the luxury apartment block in which he was staying at the time.

[137] Aside from football, Jesé is also a musician and formed a Spanish reggaeton band called Big Flow with close friend DJ Nuno in March 2014.

In November the same year, the group disbanded with Jesé announcing he would be pursuing a solo career in 2015 under the name 'Jey M.'[138][139][140] In 2018, he released a single titled La Prueba – The Proof - from which he sought to donate proceeds for research towards diseases such congenital hyperinsulinism.

He had reportedly broken COVID-19 regulations while being on a trip to the Canary Islands, and was involved in a sex scandal having supposedly cheated on his partner with her friend Rocio Amar earlier in the year.